Guojun Bu Selected Research

Apolipoprotein E2

11/2020	APOE2: protective mechanism and therapeutic implications for Alzheimer's disease.
10/2020	APOE2 is associated with longevity independent of Alzheimer's disease.
1/2020	APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.
1/2020	Interaction between APOE genotype and diabetes in cognitive decline.
5/2016	APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations.
3/2015	Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice.
5/2014	Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls.
4/2014	Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.
1/2014	Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk.

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Guojun Bu Research Topics

Disease

116	Alzheimer Disease (Alzheimer's Disease) 08/2022 - 01/2004
12	Dementia (Dementias) 01/2022 - 01/2014
12	Neoplasms (Cancer) 01/2017 - 12/2004
11	Neuroinflammatory Diseases 08/2022 - 12/2010
11	Amyloid Plaque 01/2018 - 07/2005
10	Cognitive Dysfunction 01/2022 - 01/2013
9	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2020 - 02/2011
5	Gliosis 11/2020 - 05/2015
5	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 10/2020 - 12/2007
4	Amyloidosis 01/2022 - 01/2017
4	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 01/2020
4	Parkinson Disease (Parkinson's Disease) 01/2021 - 11/2011
4	Inflammation (Inflammations) 01/2021 - 11/2005
4	Frontotemporal Dementia (Semantic Dementia) 01/2020 - 09/2015
3	Carcinogenesis 03/2015 - 12/2004
2	COVID-19 01/2022 - 01/2020
2	Chronic Renal Insufficiency 01/2022 - 01/2022
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022 - 01/2020
2	Synucleinopathies 11/2021 - 01/2020
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2020 - 01/2020
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 10/2018 - 09/2015
2	Tauopathies 10/2018 - 01/2018
2	Epilepsy (Aura) 01/2018 - 01/2016
2	Stomach Neoplasms (Stomach Cancer) 01/2016 - 03/2015
2	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 06/2010
2	Memory Disorders (Memory Loss) 12/2010 - 01/2004
2	Breast Neoplasms (Breast Cancer) 03/2010 - 09/2008
2	Neoplasm Metastasis (Metastasis) 10/2009 - 09/2008
2	Glioma (Gliomas) 03/2009 - 08/2004
2	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 06/2004 - 04/2002
1	Disease Progression 12/2021
1	Hypercholesterolemia 01/2021
1	Atherosclerosis 01/2021
1	Nervous System Diseases (Neurological Disorders) 11/2020
1	Ataxia (Dyssynergia) 10/2020
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 10/2020
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 10/2020
1	Demyelinating Diseases (Demyelinating Disease) 01/2020
1	Seizures (Absence Seizure) 01/2019
1	Multiple Endocrine Neoplasia Type 1 11/2018
1	Corticobasal Degeneration 10/2018
1	Multiple System Atrophy 01/2018
1	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 12/2017
1	Insulin Resistance 09/2017

Drug/Important Bio-Agent (IBA)

64	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2004
45	Apolipoproteins E (ApoE)IBA 08/2022 - 01/2005
40	ApolipoproteinsIBA 08/2022 - 04/2005
29	Peptides (Polypeptides)IBA 11/2020 - 07/2005
28	Proteins (Proteins, Gene)FDA Link 11/2020 - 01/2004
26	Apolipoprotein E4IBA 01/2022 - 10/2006
15	Amyloid beta-PeptidesIBA 11/2020 - 01/2004
11	Protein Isoforms (Isoforms)IBA 01/2017 - 12/2012
9	Apolipoprotein E3IBA 09/2021 - 01/2014
9	Apolipoprotein E2IBA 11/2020 - 01/2014
8	LDL Receptors (LDL Receptor)IBA 01/2017 - 04/2002
7	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2014 - 09/2007
6	LipidsIBA 01/2021 - 12/2010
5	Biomarkers (Surrogate Marker)IBA 08/2022 - 01/2017
5	CholesterolIBA 05/2016 - 01/2005
4	SynucleinsIBA 01/2022 - 11/2011
4	ProgranulinsIBA 10/2020 - 01/2016
4	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2013
4	EnzymesIBA 12/2017 - 08/2004
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2016 - 04/2008
3	beta CateninIBA 06/2010 - 12/2004
3	LigandsIBA 02/2009 - 04/2005
2	Insulin (Novolin)FDA Link 08/2022 - 09/2017
2	Adenosine Triphosphate (ATP)IBA 01/2021 - 04/2015
2	UbiquitinIBA 01/2021 - 10/2020
2	LipopolysaccharidesIBA 11/2019 - 11/2018
2	Kainic Acid (Kainate)IBA 01/2018 - 01/2016
2	Presenilin-1IBA 01/2017 - 05/2014
2	CateninsIBA 01/2017 - 01/2013
2	Pharmaceutical PreparationsIBA 01/2017 - 12/2016
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2016 - 11/2005
2	MicroRNAs (MicroRNA)IBA 04/2013 - 10/2009
2	MidkineIBA 03/2011 - 11/2007
2	Lipoprotein Receptors (Lipoprotein Receptor)IBA 01/2011 - 04/2009
2	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)IBA 03/2009 - 04/2005
1	Lipoproteins (Lipoprotein)IBA 01/2022
1	Serine (L-Serine)FDA Link 01/2021
1	Alkaline PhosphataseIBA 01/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021
1	Biological ProductsIBA 10/2020
1	Ataxin-3IBA 10/2020
1	polyglutamineIBA 10/2020
1	lysosomal proteinsIBA 10/2020
1	CuprizoneIBA 01/2020
1	Nonsense Codon (Nonsense Mutation)IBA 11/2019
1	Claudin-5IBA 01/2019
1	SynaptophysinIBA 01/2019
1	Tight Junction ProteinsIBA 01/2019
1	OccludinIBA 01/2019
1	Sirolimus (Rapamycin)FDA Link 01/2019
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 01/2018
1	Chemotactic FactorsIBA 01/2018
1	ImmunosorbentsIBA 12/2017

Therapy/Procedure

11	Therapeutics 01/2022 - 06/2005
2	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2022 - 01/2020
1	Investigational Therapies (Experimental Therapy) 12/2019